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Author

P. Northcott

2 papers indexed here

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Open access Aug 2026

Cell autonomous regional differences in oligodendrocyte lineage development and responses to oncohistone H3.3 K27M

Diffuse midline glioma, H3K27-altered (DMG), is a lethal midline brain tumor. Most DMG, unlike glioma arising in other regions, harbor histone H3.3 K27M (K27M) mutations. The basis for this anatomical selectivity remains unclear. Stem-like DMG cell transcriptomes most resemble oligodendrocyte precursor cells (OPCs). Us...

Jared M. Andrews, K. Budd, C. Kwon et al. · 0 citations
Open access Jul 2026

Circulating tumor DNA precision oncology enables effective and sensitive molecular diagnostics and actionable target detection in pediatric solid tumors - the INFORM experience

Pediatric solid high-risk malignancies mostly lack established molecular biomarkers for early detection, minimal residual disease assessment, or treatment monitoring. Challenges include small patient numbers, limited sample volumes, low tumor mutational burden, and few recurrent alterations. Within the multicenter pedi...

K. Maass, P. Puranachot, S. Volz et al. · 0 citations

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