Author

P. Nuciforo

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Open access Oct 2026

Multiomic characterization of microsatellite-stable colorectal cancer reveals distinct biology and targetable vulnerabilities.

Microsatellite-stable (MSS) colorectal cancer (CRC) is a molecularly complex and clinically challenging disease subtype, lacking effective targeted therapies. Leveraging multiomic data from ∼2,000 tumor samples (including 316MSS CRCs not previously profiled) representing ∼4,500 molecular profiles and 195,246 single cel...

A. Sadanandam, A. O'Farrell, I. Miller et al. · Cancer Cell · 1 citation

Open access Oct 2026

Clinical Outcomes and Tumor Immune Microenvironment in Epstein–Barr Virus-Positive Gastroesophageal Adenocarcinoma Treated with Immune Checkpoint Inhibitors

Epstein–Barr virus-positive gastroesophageal adenocarcinoma (EBV-GEA) is a distinct molecular subtype characterized by recurrent genomic and epigenetic alterations, frequent PD-L1/PD-L2 upregulation, and an immune-enriched tumor microenvironment. These features provide a strong biological rationale for immune checkpoin...

J. Yaringaño, S. Landolfi, R. Fasani et al. · Immuno · 0 citations

Open access Oct 2026

Talazoparib plus enzalutamide in high-volume metastatic hormone-naive prostate cancer: a randomized phase 2 trial.

Combining inhibition of poly(ADP-ribose) polymerase and androgen receptor (AR) pathway has demonstrated clinical activity in men with metastatic prostate cancer, although the extent of benefit in tumors lacking homologous recombination repair (HRR) gene alterations remains uncertain. We conducted a randomized phase 2 t...

F. Zacchi, Elena Castro, Kathleen Imbach et al. · Nature Medicine · 0 citations