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Clinical trial Open access Sep 2026

Canakinumab with chemoradiation and durvalumab consolidation in unresectable stage III non-small cell lung cancer: the phase I/II CHORUS trial

CHORUS (NCT04905316) was an open-label, non-randomized, single-arm phase I/II trial of the anti-IL-1beta monoclonal antibody canakinumab given with concurrent chemoradiotherapy and continued with anti-PD-L1 durvalumab consolidation in unresectable stage III non-small cell lung cancer. The primary endpoint was 24-month...

N. Shaverdian, M. Offin, N. Toumbacaris et al. · 0 citations
Review Open access Oct 2026

Rates of Aerodigestive Cancer After Positive mt-sDNA and Colonoscopy Without Advanced Colorectal Neoplasia in Patients with a Prior Cancer History.

BACKGROUND AND AIMS Multitarget stool DNA (mt-sDNA) testing is widely used for colorectal cancer (CRC) screening, however the clinical implications of a positive mt-sDNA results with a subsequent negative colonoscopy remain unclear especially in patients with a history of non-CRC malignancy. This study aimed to charact...

Swati Patel, J. W. Yoo, P. Paik et al. · 0 citations

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