P. Paillard

HInt: interaction-based homology discovery through accelerated genome-scale AlphaFold screening

HInt (Homology by Interaction), an accelerated AlphaFold-based framework that enables practical proteome-scale PPI prediction through biologically informed pre-filtering and optimised high-throughput structure modelling, and provides a general framework for uncovering hidden homologues and expands the conceptual landscape of protein homology inference.