P. Palumbo

Glioblastoma under chemotherapy pressure: interconnected tumor-cell adaptations shaping tumor behaviour and resistance.

Glioblastoma (GBM) is the most aggressive primary brain tumor in adults and remains largely incurable because of its marked cellular heterogeneity, limited drug delivery, and rapid development of resistance to temozolomide (TMZ). Beyond its cytotoxic activity, TMZ induces genotoxic and oxidative stress and exerts stron...