Author

P. Parchi

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Open access Sep 2026

A two-step processing method is recommended to inactivate human sporadic M1 and V2 prions

Abstract Most human-acquired prion diseases result from infection with M1 or V2 prions from sporadic Creutzfeldt–Jakob disease. To prevent transmission via surgical instruments, sterilization methods targeting these prions are essential. In this study, stainless steel wires coated with M1 or V2 prions were used to eval...

Shirou Mohri, Yuichi Matsuura, P. Parchi et al. · Journal of General Virology · 0 citations

Open access Sep 2026

Changes in five cerebrospinal fluid and three plasma Alzheimer’s disease biomarkers across increasing brain amyloid-beta and tau pathology burden

A sequential model of biomarker changes across the Alzheimer’s disease neuropathological continuum is supported, with CSF Aβ42/Aβ40 best reflects low/intermediate Aβ burden, while CSF p-tau markers are more closely related to high Aβ and intermediate tau load.

A. Mastrangelo, Simone Baiardi, Edoardo Ruggeri et al. · Acta Neuropathologica · 0 citations

Open access Jul 2026

Spatial multi-omics identifies early synaptic pruning and context-specific dopaminergic vulnerability in synucleinopathies

It is shown that early complement associated pruning of inhibitory synapses precedes overt α-synuclein aggregation and neuronal loss in prodromal synucleinopathy, indicating disease-context dependent relationships between αSyn pathology and neurodegeneration.

Svenja-Lotta Rumpf, Felix L. Strübing, Karsten Nalbach et al. · Nature Communications · 0 citations