Author

P. Pattabiraman

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Open access Oct 2026

AKT1-phosphorylated TERT assembles a FOXO3-MYC transcriptional complex that drives ERphagy and proteostasis in post-mitotic RPE.

The retinal pigment epithelium (RPE) sustains lifelong proteostasis under chronic stress, yet how post-mitotic cells activate macroautophagy/autophagy when canonical kinase pathways suppress it remains unresolved. Here we demonstrate that AKT1 (protein kinase B alpha), drives autophagy through a non-canonical transcrip...

Vishnu Suresh Babu, Sayan Ghosh, Sridhar Bammidi et al. · Autophagy · 0 citations

Review Open access Aug 2026

Clusterin as a therapeutic agent: Bridging the gap in brain and eye research.

This review discusses endogenous CLU expression, alternative splicing, and the resulting functions of its different isoforms, providing a comprehensive guide to future mechanistic studies, biomarker development, and CLU-based drug discovery across multiple brain and eye disorders.

B. Zaman, Avinash Soundararajan, P. Pattabiraman et al. · Pharmacology and Therapeutic... · 0 citations