P. Peslalz

Human myeloperoxidase-driven activation of skin sensitizing p-phenylenediamine-related aromatic diamines and phenylpropanoids-insights from in chemico and in silico approaches.

Skin sensitization is initiated by the covalent binding of low-molecular-weight chemicals to skin proteins. For prehaptens, this requires oxidative activation to generate electrophiles capable of reacting with skin proteins. While abiotic oxidation is established, enzymatic oxidation remains poorly understood. Because...