Empagliflozin promotes reverse remodeling via cardiometabolic reprogramming in established pressure-overload left ventricular hypertrophy
Left ventricular hypertrophy (LVH) due to chronic pressure overload is a major precursor of heart failure (HF) and is characterized by metabolic inflexibility and mitochondrial dysfunction. Sodium–glucose cotransporter-2 inhibitors (SGLT2i) improve HF outcomes; however, their myocardial mechanisms in LVH remain i...