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P. Pramstaller

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Open access Sep 2026

Characterization of metabolically healthy and unhealthy obesity by circulating omics.

BACKGROUND AND AIMS Individuals affected by obesity present different health trajectories and do not suffer from cardiometabolic complications all in the same way. There is a need to better understand obesity subtypes and to develop approaches for stratification. In this study we investigated metabolomic and proteomic...

G. Pontali, C. Weichenberger, Johannes Rainer et al. · 0 citations
Open access Jul 2026

Beyond the classical plasma secretome: genetic architecture and disease associations of the expanded human plasma proteome in 13,445 Europeans

Circulating plasma proteins are key biomarkers and therapeutic targets, now measurable at scale through high-throughput technologies, yet whether expanding proteomics platforms beyond the classical plasma secretome enhances genetic discovery and causal inference remains poorly understood. Here, we use an expanded SomaS...

S. Cadiou, E. Konig, A. Mapelli et al. · 0 citations
Open access Jul 2026

Dissecting the transcriptome of Parkin (PRKN)-linked Parkinson’s disease using 2D and 3D hiPSC-neuronal models

This work generates human induced pluripotent stem cell-derived midbrain dopaminergic neurons using both a 2D differentiation protocol and a recently developed 3D method based on the microencapsulation of hiPSCs in small alginate/fibronectin beads.

A. Zanon, E. Kerschbamer, D. Riekschnitz et al. · 0 citations

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