ACK family tyrosine kinases as potential therapeutic targets for cancer.
INTRODUCTION The Activated Cdc42-associated kinase (ACK) family, comprising TNK1 and ACK1/TNK2 are critical regulators of oncogenic signaling and epigenetic reprogramming. Their unique structural architecture, including ubiquitin-association domain, sterile alpha motif domain and Mig6 homology regions, distinguishes th...