The SIRT Family: Subcellular Localization and Main Functions
The mammalian sirtuins (SIRTs), consisting of seven members (SIRT 1–7), are NAD+-dependent histone deacetylases (HDACs). Similar to other classical NAD+-independent HDACs, SIRTs regulate a wide range of key biological processes by deacetylating both histone and non-histone proteins. By linking cellular metabolism to ti...