Optical Diffraction Tomography and Interpretable Machine Learning Reveal Biophysical Signatures of Gametocyte-Stage Malaria in Red Blood Cells
Accurate, stage-specific diagnosis of Plasmodium falciparum infection is critical for clinical management and transmission control of malaria. Current diagnostic tools, including Giemsa-stained microscopy and rapid diagnostic tests (RDTs), are constrained by their reliance on labeling, limited resolution, and an inab...