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Sep 2026

Analysis of Interindividual Lesion Progression Variability in Adult Cerebral Adrenoleukodystrophy.

BACKGROUND AND OBJECTIVES Cerebral adrenoleukodystrophy (cALD), the most severe clinical phenotype of X-linked adrenoleukodystrophy (X-ALD), is characterized by rapidly progressive, inflammatory destruction of the cerebral white matter. In adult patients, therapeutic options are limited to hematopoietic stem cell trans...

M. Ponleitner, J. Lier, Luc Bracoud et al. · 0 citations
Open access Jul 2026

Cerebrospinal fluid protein elevations in Alzheimer's disease are dissociated from immune cell composition

Abstract INTRODUCTION Elevated cerebrospinal fluid (CSF) inflammatory proteins have been reported in Alzheimer's disease (AD), yet whether they reflect peripheral immune cell infiltration or central nervous system (CNS)–intrinsic pathological processes remains unclear. We tested whether AD exhibits a distinct CSF prote...

Sina Zaic, T. König, O. Keritam et al. · 0 citations
Review Sep 2026

Recognition and management of acute relapse of multiple sclerosis, neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein antibody-associated disease.

The clinical patterns of acute attacks and relapses of multiple sclerosis, NMOSD and MOGAD are discussed, including the clinical and para-clinical modalities that are critical for timely recognition and diagnosis, and available evidence regarding treatment selection and responsiveness is presented.

Yu-Jing Li, Wei Jiang, Chao Zhang et al. · 0 citations
Open access Sep 2026

557. ECT-induced effects on brain structure, brain connectivity and cerebrospinal-fluid-based markers – a preliminary analysis

Abstract Background Electroconvulsive therapy (ECT) is among the most effective treatments for severe and treatment-resistant depression. Despite more than 90 years of clinical use, its underlying neurobiological mechanisms remain incompletely understood. One prominent hypothesis suggests that ECT induces neuroplastic...

P. Baldinger-Melich, S. Riessland, B. Spurny-Dworak et al. · 0 citations

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