Author

P. Siegel

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Open access Oct 2026

Serial lipoprotein(a) measurements reclassify cardiovascular risk and identify additional candidates for lipoprotein(a)-lowering therapy

Lipoprotein(a) (Lp(a)) has emerged as an important cardiovascular risk factor and is expected to become modifiable through several Lp(a)-lowering therapies in the near future. Current guidelines recommend measuring Lp(a) at least once in a lifetime, as levels are considered largely genetically determined. However...

P. Siegel, M. Gissler, M. Buechsel et al. · European Heart Journal · 0 citations

Open access Aug 2026

Transcriptomic profiling identifies tumor necrosis factor receptor-associated factor (TRAF)-5 expression in human atherosclerotic plaques as a predictor of future cardiovascular events.

AIM OF THE STUDY Tumor necrosis factor receptor-associated factors (TRAFs) are cytoplasmic adapter proteins that regulate immune cell signaling downstream of TNF, interleukin-1, and Toll-like receptors. Although preclinical data implicate TRAFs in atherogenesis, their clinical relevance in human disease remains unknown...

M. Gissler, Xin Gu, F. V. D. van der Zalm et al. · Atherosclerosis · 0 citations

Open access Aug 2026

Immunological risk identified by single-cell multi-omics and cardiovascular outcomes.

BACKGROUND AND AIMS While inflammation and (auto-)immunity are modifiers of atherosclerosis, immunological determinants of cardiovascular risk beyond the established inflammatory markers, high-sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6) remain incompletely defined in humans. This exploratory proof-o...

H. Horstmann, Nathaly Anto Michel, C. Losert et al. · European Heart Journal · 0 citations