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Author

P. Thomas

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Open access Jul 2026

Receptor allostery promotes context-specific Sonic Hedgehog signaling during embryonic development

The authors identify a binding site on the Sonic Hedgehog signaling protein Smoothened for the allosteric regulator arachidonic acid (AA) and show that its disruption attenuates SHH- and sterol-stimulated SMO induction.

M. Dillard, Christina A. Daly, Rojalin Pradhan et al. · 0 citations
Open access Aug 2026

Cytomegalovirus Modulation of CD8 T Cell Phenotype and Function in People Living with HIV-1

A subset of CMV-positive individuals with a marked expansion of CMV-specific CD8 T cells associated with markers of poor HIV-1 control are observed, which suggests an inappropriately elderly immune tone phenotype with HIV-1-CMV co-infection.

Brandi L. Clark, E. Allen, S. Schattgen et al. · 0 citations

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