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Open access Sep 2026

Pharmacological Profiling of Cannabinoid CB2 Receptor Ligands in Non-Stimulated BV-2 Microglia Cells

Microglia are key regulators of central nervous system homeostasis and neuroinflammation, and cannabinoid type 2 receptors (CB2Rs) have emerged as important modulators of microglial function. Although the pharmacology of CB2Rs has been extensively characterised in heterologous expression systems and activated microglia...

Pietro Marini, G. Bewick, M. Morgese et al. · 0 citations
Open access Oct 2026

Effects of lifelong sulforaphane intake on behavioural, neurochemical and biomolecular dysfunctions in the BTBR T+ Itpr3tf/J mouse model of autism spectrum disorders.

BACKGROUND AND PURPOSE Autism spectrum disorders (ASD) are multifactorial neurodevelopmental conditions associated with oxidative stress and neuroinflammation across critical developmental periods. Sulforaphane (SFN), a natural compound with antioxidant and anti-inflammatory properties, is a potential therapeutic strat...

Vladyslav Sikora, M. Bove, L. P. Agosti et al. · 0 citations

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