P. Turzyńska

QUALITY IN SPORT

SARCOPENIC OBESITY IN THE ERA OF INCRETIN-BASED THERAPIES: DIAGNOSTIC CHALLENGES, THE RISK OF MUSCLE MASS LOSS, AND PREVENTION STRATEGIES

Introduction and purpose. Sarcopenic obesity (SO) is defined by the coexistence of excess adiposity and reduced muscle mass and function and is associated with disability, frailty, cardiometabolic disease, and increased mortality. This review aims to summarize current evidence on the definition and diagnosis of SO, ass...

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Immunometabolism and GLP-1 Signaling in Rheumatic Diseases: Molecular Mechanisms, Clinical Implications, and Therapeutic Perspectives

BackgroundRheumatic diseases are increasingly recognized as disorders driven by both immune dysregulation and profound metabolic alterations. Glucagon-like peptide-1 receptor agonists (GLP-1RAs), initially developed for obesity and type 2 diabetes, have demonstrated pleiotropic effects extending beyond metabolic contro...

Cancer-Associated Osteoporosis and Treatment-Induced Bone Loss: Mechanisms, Prevention, and Therapeutic Strategies

Background. Cancer-associated osteoporosis and cancer treatment-induced bone loss (CTIBL) are important causes of skeletal morbidity. Fracture risk reflects the interaction of treatment-related bone loss, endocrine disruption, and deterioration of the muscle–bone unit and may not be adequately captured by bone mineral...

Exercise-induced BDNF signaling mediates neuroplasticity in depression

Background.Major depressive disorder (MDD) is increasingly recognized as a disorder of impaired neuroplasticity. Brain-derived neurotrophic factor (BDNF) plays a central role in neuronal survival, synaptic plasticity, and antidepressant mechanisms [1–4]. Physical exercise has emerged as an effective non-pharmacological...