Despite major progress with chimeric antigen receptor (CAR) T-cell therapy, multiple myeloma (MM) remains largely incurable, and most patient relapse. To broaden therapeutic options and overcome antigen escape, we explored T-cell receptor (TCR)-based targeting of intracellular antigens derived from immunoglobulin (Ig)...
M. Meeuwsen, A. Wouters, Johannes C. Wellershoff et al.· Blood· 0 citations
How cells balance these competing routes using a genome-wide CRISPR activation screen for factors that alter surface expression of CD63-an EV-associated tetraspanin that shuttles between the PM and endosomes is investigated.
Yingjie Zhong, Anna E. George, Roman I. Koning et al.· Cell Reports· 0 citations
Glycosylation of bacterial surface proteins, such as flagellin (FliC), is important for their function and is often involved in virulence of pathogens. Glycans can be further modified by so-called postglycosylation modifications (PGMs), often resulting in exclusive molecular structures. In Clostridioides difficile, a u...
P. Hensbergen, Bob van Puffelen, Nina Musch et al.· Proceedings of the National...· 0 citations
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