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Brain network formation unfolds on a nonuniform developmental timetable, with different cortical regions generating connections at different developmental phases. Generative network models (GNMs) aim to uncover the principles underpinning the organization of connectomes by creating synthetic networks according to simpl...
Significance Serotonin shapes nearly every brain circuit and is a major target of psychiatric drugs, yet how its widespread pathways are assembled has remained unclear. We combined whole-brain developmental mapping with single-cell RNA profiling to show that forebrain-projecting serotonin neurons are specified into sub...
A game-theoretic model of self-organizing neural units showing the brain is suboptimal in both cost and efficiency and computational reliability as an overlooked and perhaps even more prominent driver of brain connectivity than wiring cost or communication efficiency is presented.
A refined approach to define dynamic gene relationships is proposed, able to identify aberrant neuron-oligodendroglia interactions when applied to the study of schizophrenia.
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