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Review Open access Jul 2026

Reader-dependent functional duality of FTO: a context-switching node at the intersection of immune evasion and therapeutic resistance

This review synthesizes current evidence on FTO’s roles at the intersection of tumor immune contexture, immune checkpoint regulation, metabolic reprogramming, and therapeutic resistance and examines how FTO may contribute to immune exclusion through metabolic competition, exosomal signaling, and stromal reprogramming.

Wenjie Tian, Bin Xie, P. Zhan · 0 citations
Review Open access Jul 2026

O-GlcNAcylation at the tumor–immune interface: a metabolic post-translational code driving immune evasion and therapy resistance in cancer

This framework highlights opportunities for developing next-generation low-toxicity therapeutics, including substrate-selective inhibitors and PROTAC degraders, in rational combinations with chemotherapy, radiotherapy, and immunotherapy.

Shan-Shan Liu, P. Zhan, Wenjie Tian et al. · 0 citations

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