Sep 2026
Lactate couples metabolic state to necroptosis across pathological and physiological conditions.
How fluctuations in central metabolites are transduced into cell-death decisions remains poorly understood. Here we show that lactate directly promotes necroptosis through lactylation of receptor-interacting protein kinase 3 (RIPK3) at lysine 63 (K63). Large-scale screening identified LDH inhibition as a suppressor of...
Nai-Jin Zhang, Xin-Yue Huang, Sai-En Lu et al.
· Cell Metabolism · 0 citations