Author

Panagiotis Alexiou

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Open access Oct 2026

Argonaute 1 associates with nucleolar snoRNP machinery and regulates pre-rRNA levels and cell growth

Argonaute proteins are best known as cytoplasmic effectors of small-RNA-mediated gene silencing, although their compartment-specific functions remain incompletely understood. Here, we identify a previously unrecognized nucleolar role for Drosophila Argonaute 1 (AGO1). We observed stress-induced redistribution of AGO1 i...

Rucha Y. Hebalkar, Nils Schumann, A. S. Yatsenko et al. · bioRxiv · 0 citations

Open access Oct 2026

From Binding Sites to Target Genes: Reframing Human microRNA Target Prediction

MicroRNA (miRNA) target prediction is often treated as a single problem, yet it encompasses two distinct computational tasks: identifying whether a miRNA can bind a particular target RNA binding site, and predicting the change in gene expression that follows from miRNA perturbation. Here, we trace the evolution of the...

S. Sammut, E. Zacharopoulou, Dimosthenis Tzimotoudis et al. · Non-Coding RNA · 0 citations