Panpan Zhang

Massively Parallel, Single-Molecule Assessment of Synthetic Fidelity and Drug-Like Properties in a DNA-Encoded Library.

LC-seq is introduced, a sequencing-based chromatographic strategy that simultaneously assesses synthetic fidelity and permeability-relevant lipophilicity for individual library members and enables direct, per-member assessment of compound quality and lipophilicity, with projected scalability to libraries of millions.