Optimization of transient anti-CD3 (OKT3) monoclonal antibody expression in Nicotiana benthamiana
The research aimed to develop a production platform for the OKT3 (Muromonab-CD3) monoclonal antibody, which specifically targets the CD3 receptor on T-lymphocytes, using Nicotiana benthamiana and the geminiviral transient expression system (pBYR2e). The heavy and light chain genes of OKT3 were codon-optimized for the h...