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Author

Paramita Pal

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Open access Oct 2026

Intrinsic Reactivity of Sulfonyl Imidazole and Triazole Electrophiles for Covalent Probe Design.

Sulfonyl exchange electrophiles are increasingly used in covalent probe and drug discovery, yet their intrinsic reactivity and plasma stability remain poorly defined, limiting rational warhead selection. Here we establish a systematic LC-MS framework to quantify the reactivity of sulfonyl imidazole and triazole electro...

Paramita Pal, Hannah M. Unsworth, Lyn H. Jones · 0 citations

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