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Author

Pareshkumar N. Patel

3 papers indexed here

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Review Open access Sep 2026

Oncolytic virotherapy at the tumor microenvironment-CAR Therapy interface: Mechanisms, clinical translation, and future directions.

Oncolytic virotherapy has evolved from a tumor-selective cytolytic strategy into a programmable immunotherapeutic platform that reshapes the tumor microenvironment (TME). Oncolytic viruses (OVs) selectively infect malignant cells, induce immunogenic cell death, release tumor antigens, and activate innate and adaptive i...

A. Atoom, J. Rizaev, D. Polatova et al. · 0 citations
Review Open access Sep 2026

Targeting the Immunosuppressive Microenvironment in Colorectal Cancer: Pharmacological and Nanomedicine Strategies

The immunosuppressive stroma in colorectal cancer (CRC) plays a central role in therapeutic resistance. Modulating key targets within this stromal compartment has been proposed as a promising strategy for restoring antitumor immunity and overcoming resistance mechanisms. Several immunomodulatory agents, including next-...

Qamar Abuhassan, Usamah Sayed, Pareshkumar N. Patel et al. · 0 citations
Review Sep 2026

Advances in Novel Drug Delivery Systems for Targeting the Brain: Overcoming Barriers and Enhancing Therapeutic Efficacy.

The blood-brain barrier (BBB) is critical in CNS pharmacotherapy; it blocks the entry of 98 per cent of small-molecule compounds and almost all macromolecules into the brain parenchyma via tight junction complexes, efflux transporter action, and enzymatic breakdown. This review focuses on the mechanistic basis of BBB r...

Manish R. Bhise, K. Thejomoorthy, Mohit Kumar et al. · 0 citations

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