Design of a next-generation multi-target multi-epitope tuberculosis vaccine using an epitope order optimization approach: A 500 ns molecular dynamics study.
BACKGROUND Multi-epitope-based peptide (MEBP) vaccines have emerged as promising alternatives to conventional vaccines for combating Mycobacterium tuberculosis (M.tb) infection. Current immunoinformatics-based MEBP vaccine design strategies typically construct a single vaccine candidate by assembling the selected epito...