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Underlying tissue destruction in Definite vs Probable PRLs in people with progressive MS is assessed using quantitative MRI to assess underlying tissue destruction in PRLs in people with progressive MS.
Recent updates to the diagnostic criteria of multiple sclerosis (MS) require whole‐brain T2*‐weighted (T2*w) imaging with submillimeter resolution to detect novel diagnostic biomarkers such as the central vein sign. However, to achieve the needed submillimeter spatial resolution, conventional T2*w 3D gradient‐echo scans sequences are limited by prohibitively long scan times for clinical use. Here, we evaluated a different approach based on a segmented 3D echo planar imaging (3D‐EPI) sequence, accelerated with 2D Controlled Aliasing in Parallel Imaging Results in Higher Acceleration (CAIPIRINHA) undersampling and denoised with a deep learning‐based network.
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