Patrick Appiah-Kubi

4-Aminoquinoline derivatives and benzoxaborole-4-aminoquinoline hybrids: synthesis, antiplasmodial evaluation, heme-inhibition and in silico studies

UV-visible spectroscopic titrations demonstrated that compound 8b binds monomeric heme more selectively than CQ at both physiological and digestive vacuole pH, supporting inhibition of hemozoin formation as its primary mode of action.