Open access
Feb 2026
Disruption of the insulin/IGF-1 signaling pathway in Caenorhabditis elegans dramatically increases male longevity and enhances reproductive health late in life.
It is shown that ubiquitous degradation of DAF-2 in male C. elegans increases median lifespan by more than 440%, one of the longest lifespan extensions by a single intervention to date.
Rose S. Al-Saadi, Hannah B. Lewack, Patrick C. Phillips
· Aging · 0 citations