Caenorhabditis Intervention Testing Program: all-trans retinoic acid lifespan extension in Caenorhabditis elegans requires 5-Fluoro-2'-deoxyuridine (FUdR)
The Caenorhabditis Intervention Testing Program recently characterized the longevity-promoting effects of all-trans-retinoic acid (atRA) in C. elegans . While we observed that atRA extended lifespan across multiple genetic backgrounds, environmental factors may influence its efficacy. One such factor is 5-Fluoro-2'-deo...