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Author

Patrick da Silva

2 papers indexed here

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Open access Sep 2026

Brain-resident myeloid cells promote rapid leukocyte adhesion in leptomeningeal vessels after anti-Aβ immunotherapy

Anti-amyloid-β (Aβ) immunotherapy improves cognitive outcomes in Alzheimer’s disease (AD) but is associated with amyloid-related imaging abnormalities (ARIA), through poorly understood mechanisms. To define how anti-Aβ antibodies acutely engage brain immune and vascular compartments, we developed a longitudinal in vivo...

Moustafa Algamal, Shinya Yokomizo, Wadzanai Ndambakuwa et al. · 0 citations
Jul 2026

Integrated multiomics profiling reveals MS-specific molecular signatures linked to progression and response to nasal anti-CD3 (Foralumab) therapy 2267524

Chronic neuroinflammation in multiple sclerosis (MS) can persist independently of relapse activity, revealing mechanisms of progression not addressed by current therapies. Dysregulated T-cell activity plays a central role in this process and is the main target of nasal Foralumab immunotherapy. Here, we aimed to i...

Ronaldo S. Francisco, Thais G. Moreira, Patrick da Silva et al. · 0 citations

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