Patrizia Polverino de Laureto

Thrombin reshapes α-synuclein biochemical properties by N-terminal truncation

Proteolytic processing of α-Synuclein (Syn) contributes to the molecular diversity and toxicity of its aggregates in Parkinson’s disease, yet the proteases responsible for disease-relevant truncations remain incompletely defined. Here, we show that thrombin, a serine protease associated with inflammatory conditions,...