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Author

Paul J. Sampognaro

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Open access Aug 2026

A neuronal CRISPRi screen identifies PQLC2 as a lysosomal pH regulator controlling tau homeostasis

Lysosomes make key contributions to the maintenance of cellular proteostasis, and their functional compromise has been linked to aging and neurodegenerative disease. A defining characteristic of lysosomes is their relative acidity compared to other subcellular compartments, a quality that enables the efficient breakdow...

Mackenzie Welch, Paul J. Sampognaro, Shun-Pan Shu et al. · 0 citations

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