Paul J Thornalley

Hexokinase-2-glycolytic overload axis in brain disorders exacerbated by diabetes.

Subjects with diabetes have an increased risk of dementia, Parkinson's disease, and stroke. In the central nervous system, there is increased inflammation, blood-brain barrier permeability, amyloid-β and α-synuclein deposition, and decreased neuronal synaptogenesis and survival. The role of hexokinases in controlling g...