Dihydroorotate Dehydrogenase Inhibitors are Potent Antiviral Agents against Henipaviruses and Arenaviruses.
Hendra virus (HeV) and Nipah virus (NiV) are zoonotic henipaviruses associated with high mortality and are classified as Biosafety Level 4 (BSL-4) agents. To identify small molecule inhibitors, we performed a cell-based high-throughput screening (HTS) of an antiviral compound library using recombinant Cedar virus (rCed...