Author

Paul Aisen

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Open access Oct 2026

ATRI LIMS: a cloud-native open-source laboratory information management system for biomarker-driven Alzheimer’s disease clinical trials

Abstract Objectives This article summarizes the architecture, design principles, and implementation strategy of the ATRI Laboratory Information Management System (LIMS), a cloud‑native, open‑source platform supporting biomarker‑driven Alzheimer’s disease (AD) clinical research. The system addresses challenges associate...

G. Jimenez-Maggiora, S. Bruschi, S. Abdel-Latif et al. · JAMIA Open · 0 citations

Open access Sep 2026

Sex-specific biological aging clocks across organs and omics

Developing 38 sex-specific biological aging clocks across 15 organ systems and 4 omics layers reveals sex-specific biological aging signatures in aging, AD, and systemic health, highlighting the need for explicitly sex-stratified modelling approaches.

Zhi-Yuan Song, Derek Feng, Naowal Azraf Rahman et al. · Nature Medicine · 0 citations

Open access Sep 2026

CSF proteomics and machine learning reveal distinct stages across the Alzheimer’s disease continuum

These findings uncover protein signatures that reflect underlying AD biology and provide a foundation for stage-specific biomarkers and therapeutic targeting, with important implications for patient stratification and personalized intervention strategies.

Saima Rathore, E. Dammer, Anantharaman Shantaraman et al. · Molecular Neurodegeneration · 0 citations