Bacteriophages are major ecological drivers of gut microbial ecology, yet whether bacterial mechanisms that determine phage susceptibility have consequences for the mammalian host remains poorly understood. Here, we identify dipeptidyl peptidase 11 (Dpp11a), the predominant active serine protease of the prevalent gut c...
Ning Qu, Marlène S. Birk, Thomas C. A. Hitch et al.· bioRxiv· 0 citations
Summary Mobile genetic elements (MGEs) drive horizontal gene transfer in prokaryotes, disseminating antimicrobial resistance genes (ARGs), virulence factors (VFs) and biosynthetic gene clusters (BGCs). Given their importance, there is a pressing need for a single, open source tool that annotates the MGE repertoire toge...
Alejandra Escobar-Zepeda, Martin Beracochea, Tatiana A. Gurbich et al.· bioRxiv· 0 citations
This perspective highlights recent advances in multi-omics microbiome research, outlines key obstacles in data integration and metadata harmonization, and proposes a collaborative roadmap for scalable, FAIR-compliant multi-omics investigations and potentially disruptive Artificial Intelligence advances.
T. Van Den Bossche, Eunice Lazau, Velma T. E. Aho et al.· Nature Communications· 0 citations
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