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Author

Paula A. Schneider

1 paper indexed here

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Open access Sep 2026

BCLXL blockade rewires cell fate to overcome PARP inhibitor resistance in ovarian cancer

Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPis) induce regressions and extend progression-free survival (PFS) in ovarian cancer, especially in tumors with BRCA1 or BRCA2 mutations that impair homologous recombination repair. While recent studies have clarified the key roles of BRCA1, BRCA2, and PARP1 in replicat...

A. Venkatachalam, Annabella R. Strathman, Xia Hou et al. · 0 citations

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