Author

Paula Fong

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Jul 2026

Abstract B088: A cryptic alternative bound state of HDAC6 drives mutation- and ligand-dependent remodeling of inhibitor interaction

A cryptic, mutation-accessible conformational state of HDAC6 that fundamentally alters inhibitor binding is revealed and suggests that HDAC6 inhibitor optimization—and resistance prediction—must explicitly account for multiple bound states.

Paula Fong, Fan Yuan · Clinical Cancer Research · 0 citations