Vimentin remodeling in response to oxidants and electrophiles is modulated by pH
Vimentin is critical for cell mechanosensing, cytoskeletal cross-talk, and stress responses and is finely tuned by posttranslational modifications. Vimentin single cysteine, C328, is a modification hotspot, essential for filament remodeling by oxidants and electrophiles. With a pKa near physiological pH, C328 reactivit...