Open access
Sep 2026
Quality by design-assisted development of an intranasal Shikonin-loaded Mucoadhesive microemulsion for enhanced brain delivery: optimization, characterization, and Pharmacodynamic evaluation in a schizophrenia model.
The present study aimed to develop and optimize a shikonin-loaded mucoadhesive microemulsion for intranasal delivery with the objective of improving nasal residence and facilitating central drug delivery. Shikonin is a naturally occurring naphthoquinone derivative with reported anti-inflammatory and neuroprotective pro...
Pavan Kumar Inuganti, K. Gandla, Lalitha Repudi et al.
· Bioorganic chemistry (Print) · 0 citations