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Pavaret Sivapornnukul

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Open access Aug 2026

The microbiome determines the phenotype in CTLA-4 insufficient mice and men

CTLA-4 (haplo)insufficiency displays incomplete penetrance and phenotypic heterogeneity, indicating the involvement of additional disease modifiers beyond the genetic defect. Microbiome analyses reveal a positive association between disease severity and intestinal dysbiosis, highlighting the microbiome as a critical co...

Bei Zhao, Lara Stopp, Pavaret Sivapornnukul et al. · 0 citations

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