Author

Pavel V. Shliaha

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Open access Oct 2026

WEE1 opposes APC/CCDH1 activity to promote S phase entry.

WEE1 phosphorylates and inhibits the activity of cyclin-dependent kinases to prevent mitotic entry and establish a G2 DNA damage checkpoint1-3. Consequently, WEE1 inhibitors have been developed to be synthetically lethal in TP53-mutated tumours that become reliant on this WEE1-mediated checkpoint, and such inhibitors a...

Luc-Alban Vuillemenot, Lucas G. Morales, Calin-Mihai Dragoi et al. · Nature · 0 citations

Open access Aug 2026

Chromatin is dispensable for bacterial life

The successful construction of ΔNAP9 demonstrates that bacterial cells can carry out basic cellular functions in the absence of co-evolved chromatin proteins, highlighting the potential for radical (re-)engineering of prokaryotic chromatin and systems of gene expression.

Paul Villain, A. Hocher, Jacques Serizay et al. · bioRxiv · 1 citation