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Paweł Stączek

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Open access Sep 2026

New antifungal and less toxic zwitterionic derivatives of 26-membered polyene antibiotic – pimaricin containing N-benzyl and N-alkyl moieties and their molecular mechanism

Abstract N-derivatives of pimaricin (PIM) were synthesised as zwitterions or in a non-ionic form, influencing water solubility and toxicity in normal cells (HDF). The introduction of benzyl-O-aliphatic (15) and methylene-nitrophenol (7) moieties into the polyene resulted in high and broad-spectrum antifungal activities...

Ewelina Smolarz, Adam Buczkowski, W. Schilf et al. · 0 citations

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