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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Pei Huang

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Open access Sep 2026

MED24 deficiency promotes R-loop accumulation and sensitizes to SN-38 in triple-negative breast cancer

The application of DNA topoisomerase I (TOP1) inhibitors in triple-negative breast cancer (TNBC) still needs to be optimized. The principle of synthetic lethality represents a promising strategy to optimize TNBC treatment using SN-38, a representative TOP1 inhibitor and the active metabolite of irinotecan. MED24, yet...

Tao Shen, Xin-Hua Liu, Pei Huang et al. · 0 citations

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