Author

Pei-Jun Zhang

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Open access Sep 2026

Unveiling structural determinants of peptide recognition by public and private SARS-CoV-2-specific T-cell receptors

Public T cell receptors (TCRs) recurrently emerge across individuals in response to common pathogens, yet the structural and biophysical basis distinguishing public from private clonotypes remains incompletely defined. Here, we combine epitope mapping, single-cell TCR sequencing, and single-particle cryo-electron m...

Caner Akıl, Yan-Chun Peng, Julia McCarthy et al. · Nature Communications · 0 citations

Open access Sep 2026

In-cell structural analysis reveals a distinctive chloroplast ribosome in Chlamydomonas reinhardtii

Chloroplast ribosomes synthesize plastid-encoded components of photosynthetic machinery, yet their structure and organization remain poorly understood. We combined cryo-focused ion beam milling, cryo-electron tomography and subtomogram averaging to determine native chloroplast ribosomes in Chlamydomonas reinhardtii. Th...

Zhen Hou, Yao Shen, Zhao-Bo Zhang et al. · bioRxiv · 0 citations

Open access Jul 2026

Structural dynamics of RNA polymerase II throughout the nucleotide addition cycle

These findings define a comprehensive structural and dynamic framework for RNAPII NAC, yielding a “molecular movie” of RNAPII in action and revealing a fundamental principle by which the enzyme balances speed and fidelity through coordinated conformational dynamics.

Gangshun Yi, Qing-Rong Li, H. Holmberg et al. · Nature Communications · 1 citation