Sep 2026
WTAP-mediated m6A modification upregulates the circCDK8 to promote ferroptosis in periodontal ligament stem cells.
Investigating the role of WTAP in LPS-induced ferroptosis in PDLSCs reveals that WTAP drives ferroptosis in PDLSCs through m6A-dependent stabilization of circCDK8, which activates the let-7a-5p/TFRC and YBX1/ACSL4 axes, offering mechanistic insights for alveolar bone repair.
Xu Yang, Pei-Kun Shi
· Biochemical Pharmacology · 0 citations