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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Pei-Wen Wu

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Aug 2026

A Self‐Framed Nanoprodrug for Orchestrating Mitochondria‐Associated Membranes‐Mediated Cascade Amplification Loop to Potentiate Radiotherapy in Esophageal Squamous Cell Carcinoma

Radioresistance remains a pivotal factor in the failure of esophageal squamous cell carcinoma (ESCC) therapy. Here we report a hyaluronic acid‐modified, polyphosphazene‐based self‐scaffold nanoradiosensitizer (HDiSeH) that addresses the limitations of single‐organelle targeting. HDiSeH exhibited uniform nanoscale m...

Pei-Wen Wu, Wei-Bin Hu, Ming-Chao Mu et al. · 0 citations
Sep 2026

The tire antioxidant derivative 6PPD-quinone exacerbates IBD by targeting NR1H4-mediated lipid metabolism and mitochondrial dysfunction in human colon epithelial cells.

N- (1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6PPD-Q), a tire rubber antioxidant derivative, accumulates in air, soil, and water and has been found in urine, blood, and cerebrospinal fluid, posing significant health risks. Although 6PPD-Q exhibits intestinal toxicity, its role in inflammatory bowel disea...

Pei-Wen Wu, Wei-Bin Hu, Gang Chen et al. · 0 citations

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